Research

Biochemistry and Biophysics Building

     

About Research in the Rye Lab

The Rye Lab occupies approximately 1500 square feet of modern laboratory space on the second floor of the Biochemistry and Biophysics building.  The lab contains ample wet bench space, as well as specialized equipment rooms for fluorescence, stopped-flow and single molecule systems.

We are broadly interested in understanding how the conformational states of proteins and cellular membranes are monitored and controlled inside a living cell.  Using bacteria and yeast as model systems, we employ a variety of methods, including genetics, protein mutagenesis, fluorescence spectroscopy, stopped-flow kinetics and single-molecule fluorescence burst analysis.  Projects in the lab cluster into two thematic areas involving (1) protein dynamics and molecular chaperone function and (2) membrane dynamics.  Our goal is to develop mechanistic and quantitative explanations for how molecular chaperone networks sense and control protein folding and how proteins are used to control membrane fission and fusion.

Department of Biochemistry and Biophysics                           Texas A&M University              2017